Abstract：Aiming at the challenge of demand response uncertainty to the safe and economical operation of

integrated energy system，a cooperative optimal scheduling model of multi-region integrated energy system

considering thermal pipe network transmission and demand response was proposed. Firstly，the energy transmission model of heat network was modeled in fine detail. Secondly，the demand response strategy was adopted for the comprehensive load，and the information gap decision theory was adopted to deal with the output uncertainty of renewable energy. Finally，the day-ahead operation scheduling scheme of the integrated energy system was proposed with the minimum dispatching cost and carbon emission penalty as the optimization objective，and various constraints were considered comprehensively. An example analysis proves that the proposed model can improve the economy of the system and the ability to absorb renewable energy.

      Key words：multi-region integrated energy system；demand response uncertainty；heat network coupling；

renewable energy consumption